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They say the huge population study is a big step in understanding the risk of type 2 diabetes among South Asians.
The study, entitled Diabetes (Diabetes Meta-Analysis of Trans-Ethnic Association Studies), was co-led by Professor Andrew Morris of the University of Manchester.
According to the study, the global incidence of type 2 diabetes has quadrupled in the last 30 years. South Asia, especially India and China, are the main centers of this wave. It is thought that Indians are particularly at risk for type 2 diabetes because they are centrally obese. It is an indicator of fat around their visceral organs and is more insulin resistant from birth.
This is in contrast to the Europeans, who are generally obese in a general way. Despite this fact, the largest studies to understand the genetic basis of type 2 diabetes have been conducted on a population of mostly European descent.
Dr. Giriraj R. Chandak, lead scientist at CCMB and one of the leading researchers in India, says the current study is a landmark event where scientists from around the world have teamed up to understand the similarities and differences between the genetic susceptibility of type 2 diabetes. Between different populations.
The team, led by Dr. Chandak, previously provided evidence of greater genetic diversity among Indians than Europeans, compromising our ability to predict the risk of type 2 diabetes in the Indian population using European data.
“This recent study compared the genomic DNA of 1.8 million people with type 2 diabetes to 11.6 million normal subjects of five ancestors – European, East Asian, South Asian, African and Hispanic, and identified a large number of genetic differences (single nucleotide polymers). SNPs). Between the patient and the normal subject, “said Dr. Chandak.
CCMB Director Dr Binoy Nandikuri said recent research has created a platform for further research into the genetic susceptibility of type 2 diabetes in the South Asian population and has paved the way for the right medicine.