IISC team finds way to block a superbug transporter – Times of India

BENGALURU: Researchers at the Molecular Biophysics Unit (MBU) of the Indian Institute of Science (IISC) have found a fancy way to prevent bacteria from excreting antibiotics that help them resist drugs.

The new discovery has the potential to make existing drugs more effective against drug-resistant bacteria or superbugs.


What they basically did was block a specific antibody (camel, found in the National Research Center on Camels) found in Indian camels, which helps the bacteria get the drug out. Currently, the team, led by Arvind Penmats, an assistant professor at MBU, is looking into the condition of the laboratory.


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Bacteria usually die through the use of antibiotics. One of the methods they use to achieve immunity is called efflux – a process by which bacteria transport drug-like compounds outside the cell – and transporters play a key role in activating the bacterium.

Understanding the molecular architecture of these cell membrane-embedded machines facilitates the design of inhibitors against transporters that are one of the main components of the bacterial multidrug resistance arsenal, thereby helping to treat this bacterial disease.


And, according to IISC, in a new study, researchers have “complexly solved the atomic-resolution structure of such a transporting narcissus, including Indian camouflage antibodies (ICAB).”

Although transporters are molecular devices that require stratification to transfer their shape (structure / structure), the team has observed that by binding ICAB to Norsey it is bound as a single unit.

Not only is the transporter stuck in a single state, ICAB effectively plugs the transporter like a “bottle-cork”, making it unable to interact with antibacterial compounds (drugs).


“… The efflux process is very important for bacteria and a major strategy that has not yet been explored as a therapeutic mechanism is to create molecules that can block efflux. If we are able to block certain transporters that help the flow of some antibiotics, Those drugs will be effective. In some ways, we can increase the effectiveness of the available antibiotics if we have an eflux blocker and this is the potential medical benefit of what we have received. ”

Narcissus Staphylococcus aureus is a transporter এক a type of bacterium that is often found in the skin and upper respiratory tract মানুষের that helps provide resistance to broad-spectrum antibiotics such as norfloxacin and moxifloxacin.

“These insights will significantly help in the development of strategies against transporter-mediated antibiotic resistance in pathogenic bacteria using tools such as camouflage antibodies. The structure of Norsi and the form in which it is resolved are also of the first type, providing a model for studying the flow carriers of similar drugs from other pathogenic bacteria, ”IISC added.


The study was initially funded by the DBT-Welcome Trust India Alliance and the Department of Biotechnology.

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