IIF Hyderabad co-designs molecules to improve IVF success rate – Times of India

HYDERABAD: Scientists in Hyderabad, Mangalore and Manipal have designed an organic molecule that enhances the functional efficiency of sperm used for in vitro fertilization (IVF).

The small organic molecule MPTX is manufactured by Prince Irappar Group from the Department of Biotechnology, IIT Hyderabad; Jagadish Prasad Dasappar team from University of Mangalore; And Guruprasad Kalthur Group from Kasturba Medical College, Manipal Higher Education Academy.



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Their study found that MPTX, a pentoxifylline derivative, is able to increase sperm motility, extend in vitro sperm survival, and improve sperm fertilization without adversely affecting fetal development at much lower concentrations than the widely used pharmacological agents. – Pentoxifylline in IVF technology. Compared to existing drugs, MPTX molecule is a potentially better pharmacological agent for assisted reproductive technology.


“Our multi-institutional partner team is coming up with a formulation using this combination of MPTX and other molecules, which may be more effective than existing formulas,” said Prince Irappa, associate professor, Department of Biotechnology, IIT-H.

With an estimated 48 million infertile couples worldwide, decreased sperm motility is one of the leading causes of male infertility. Mobility is essential for sperm to reach the place of fertilization during natural pregnancy. In addition, the percentage of dynamic sperm present in ejaculation helps to determine the ideal artificial insemination method, such as IVF, for the treatment of infertility.

Pentoxifylline treatment increases sperm motility which goes into gloves with unintended premature acrosomal reactions, which together determine the success of IVF. The purpose of this DST-SERB-funded project was to improve the efficacy of pentoxifylline and reduce its adverse effects on sperm efficiency and fetal development.


Speaking on the technological advancement, BS Murthy, Director, IIT Hyderabad, said, “The joy of fatherhood cannot be defined in words. Work led by Prince Irappa and his associates can bring happiness to the parents of infertile couples, increasing the success rate of IVF.”

“IIT-H is an institution that nurtures talents in both the biomedical and biotechnology departments separately. It also demonstrates the power of consistent collaboration. I believe that many technologies that significantly impact society will continue to evolve at IIT-H continuously.”

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